George F Koob Selected Research

Buprenorphine (Subutex)

8/2012	A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence.
1/2005	Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats.

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George F Koob Research Topics

Disease

45	Alcoholism (Alcohol Abuse) 01/2023 - 04/2002
18	Substance-Related Disorders (Drug Abuse) 01/2019 - 07/2004
17	Cocaine-Related Disorders (Cocaine Addiction) 01/2017 - 01/2002
16	Opioid-Related Disorders (Opiate Addiction) 03/2023 - 07/2002
8	Hypersensitivity (Allergy) 01/2018 - 02/2008
7	Hyperalgesia 12/2023 - 07/2010
7	Pain (Aches) 12/2023 - 07/2010
7	Heroin Dependence (Heroin Abuse) 01/2019 - 07/2011
7	Tobacco Use Disorder (Nicotine Dependence) 01/2015 - 02/2004
4	Body Weight (Weight, Body) 01/2019 - 01/2003
3	Inflammation (Inflammations) 04/2024 - 01/2019
3	Chronic Pain 05/2021 - 01/2015
3	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/2021 - 11/2008
3	Neuroinflammatory Diseases 01/2019 - 07/2014
3	Seizures (Absence Seizure) 01/2007 - 02/2004
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2022 - 02/2012
2	Parkinson Disease (Parkinson's Disease) 11/2020 - 07/2014
2	Mental Disorders (Mental Disorder) 08/2018 - 01/2012
2	Binge Drinking 01/2011 - 02/2008
2	Hyperphagia (Overeating) 11/2009 - 03/2006
2	Encephalitis (Encephalitis, Rasmussen) 01/2007 - 03/2006
2	Epilepsy (Aura) 03/2006 - 02/2004
2	Morphine Dependence 10/2004 - 02/2003
1	Opiate Overdose 01/2023
1	Respiratory Insufficiency (Respiratory Failure) 01/2023
1	Ataxia (Dyssynergia) 11/2022
1	Ketosis 01/2021
1	Brain Injuries (Brain Injury) 01/2020
1	Ischemia 01/2020
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2020

Drug/Important Bio-Agent (IBA)

20	Corticotropin-Releasing HormoneIBA 01/2022 - 10/2002
17	Opioid Analgesics (Opioids)IBA 12/2023 - 08/2005
15	Heroin (Diamorphine)IBA 12/2023 - 12/2006
15	Ethanol (Ethyl Alcohol)IBA 01/2021 - 04/2002
10	Cocaine (Cocaine HCl)IBA 01/2020 - 01/2002
8	Dynorphins (Dynorphin)IBA 05/2021 - 02/2004
8	gamma-Aminobutyric Acid (GABA)IBA 01/2019 - 02/2003
6	Naloxone (Narcan)FDA LinkGeneric 03/2023 - 01/2005
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2004
6	VaccinesIBA 05/2013 - 03/2011
5	Nicotine FDA Link 04/2015 - 07/2010
5	Opiate AlkaloidsIBA 12/2013 - 07/2002
4	LigandsIBA 03/2023 - 06/2010
4	Dopamine (Intropin)FDA LinkGeneric 11/2020 - 04/2002
4	CRF receptor type 1IBA 01/2018 - 04/2009
4	Naltrexone (ReVia)FDA LinkGeneric 08/2012 - 02/2008
4	Neuropeptide YIBA 06/2011 - 02/2003
4	Neurotransmitter Agents (Neurotransmitter)IBA 06/2011 - 01/2002
4	CannabinoidsIBA 04/2009 - 04/2002
4	Morphine (MS Contin)FDA LinkGeneric 11/2008 - 07/2002
3	Ghrelin ReceptorsIBA 01/2023 - 01/2019
3	Opioid Receptors (Opioid Receptor)IBA 01/2022 - 08/2012
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 09/2006
3	Glutamic Acid (Glutamate)FDA Link 01/2011 - 02/2003
3	Opioid Peptides (Opioid Peptide)IBA 01/2011 - 01/2003
3	Acamprosate (Campral)FDA Link 01/2010 - 01/2005
2	Analgesics (Analgesic Drugs)IBA 12/2023 - 05/2021
2	Fentanyl (Sublimaze)FDA LinkGeneric 03/2023 - 01/2023
2	Interleukin-17 (Interleukin 17)IBA 03/2023 - 01/2020
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2022 - 01/2021
2	Mifepristone (RU 486)FDA Link 01/2022 - 08/2015
2	Acetates (Acetic Acid Esters)FDA Link 01/2021 - 01/2021
2	Aldehyde DehydrogenaseIBA 01/2021 - 12/2019
2	EnzymesIBA 12/2019 - 11/2006
2	Messenger RNA (mRNA)IBA 11/2019 - 01/2017
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 04/2015 - 02/2011
2	Propranolol (Inderal)FDA LinkGeneric 03/2015 - 10/2010
2	kappa Opioid Receptors (kappa Opioid Receptor)IBA 10/2013 - 06/2010
2	Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)IBA 04/2013 - 04/2011
2	Narcotic Antagonists (Opioid Antagonists)IBA 08/2012 - 01/2007
2	Buprenorphine (Subutex)FDA LinkGeneric 08/2012 - 01/2005
2	Norepinephrine (Noradrenaline)FDA LinkGeneric 10/2010 - 07/2008
2	EndocannabinoidsIBA 04/2009 - 04/2002
2	Methamphetamine (Desoxyn)FDA LinkGeneric 07/2007 - 03/2006
2	UrocortinsIBA 05/2007 - 08/2002
2	Anticonvulsants (Antiepileptic Drugs)IBA 01/2007 - 03/2006
2	Serotonin (5 Hydroxytryptamine)IBA 02/2003 - 07/2002
1	Proprotein Convertase 9IBA 04/2024
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2023
1	CC ChemokinesIBA 03/2023
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2023
1	Spironolactone (Aldactone)FDA LinkGeneric 11/2022
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2022
1	GhrelinIBA 01/2022
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022
1	AcyltransferasesIBA 01/2022
1	norbinaltorphimineIBA 05/2021
1	17- cyclopropylmethyl- 6,7- didehydro- 4,5- epoxy- 5'- guanidinyl- 3,14- dihydroxyindolo(2',3'- 6,7)morphinanIBA 05/2021
1	acetoacetic acid (acetoacetate)IBA 01/2021
1	KetonesIBA 01/2021
1	Ketone BodiesIBA 01/2021
1	PlacebosIBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	EstersIBA 01/2021
1	AcetoneIBA 01/2021

Therapy/Procedure

19	Self Administration (Administration, Self) 01/2019 - 10/2002
11	Therapeutics 01/2023 - 11/2008
7	Drug Therapy (Chemotherapy) 11/2022 - 08/2003
2	Analgesia 05/2021 - 11/2012
2	Ketogenic Diet 01/2021 - 01/2021